MHB3 is a patent pending, modified hyaluronan biopolymer with superior oral absorption and bioavailability characteristics.38 It is marketed as a dietary supplement ingredient for Systemic Arthrosupplementation™ with supportive fundamental scientific and clinical research. MHB3 is molecularly engineered using a proprietary process that assures consistency in molecular profile, molecular weight, and polydispersity.
Extra-cellular microbial production assures that MHB3 is pure, consistent and vegan. Microbial production eliminates concerns about extraneous proteins from animal derived raw materials. MHB3 is not genetically modified and does not contain any genetically modified ingredients.
Studies show that orally administered MHB3 can interrupt inflammatory processes36, modify the course of disease progression40, and relieve the symptoms of osteoarthritis and chronic joint pain36. The fundamental basis for these findings lies in the normal role of hyaluronan in the healthy subject. MHB3 is therefore recommended for long-term maintenance of critical joint structures and for ongoing anti-inflammatory prophylaxis.
Researchers at the London Health Sciences Center have shown that oral administration of MHB3 formulations leads to a change in the size distribution of hyaluronan in the plasma.38 Specifically, the proportion of hyaluronan that is high molecular weight — anti-inflammatory42 — is increased38, and the proportion of hyaluronan that is low molecular weight — pro-inflammatory42 — is decreased38. The fundamental mechanism underlying these findings remains to be elucidated, but the results are consistent with other studies showing hyaluronan of the molecular weight range increased in the present study to be anti-inflammatory when delivered orally.42
